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Oligonol® Published Papers

Oligonol®の論文

Oligonol® Published Research List

・Supplementation with Oligonol, Prevents Weight Gain and Improves Lipid Profile in Overweight and Obese Saudi Females
Suhad Matoug Bahijri (King Abdulaziz University, Saudi Arabia), et al.
Current Nutrition & Food Science, 13(4) (2017)
・Global Liver Gene Expression Analysis on a Murine Metabolic Syndrome Model Treated by Low-molecular-weight Lychee Fruit Polyphenol (Oligonol(R))
Koji Wakame (Hokkaido Pharmaceutical University School of Pharamacy, Japan), et al.
Anticancer Research, 36(7): 3705-3713 (2016)
・Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, protects the pancreas from apoptosis and proliferation via oxidative stress in streptozotocin-induced diabetic rats
Chan Hum Park (National Institute of Horticultural, Takako Yokozawa (University of Toyama, Japan), et al.
Food & Function, 7(7): 3056-3063 (2016)
・Flavanol-rich lychee fruit extract alleviates diet-induced insulin resistance via suppressing mTOR/SREBP-1 mediated lipogenesis in liver and restoring insulin signaling in skeletal muscle
Hung-Wen Liu, Weia, Sue-Joan Chang, et al. (National Cheng Kung University, Taiwan)
Molecular Nutrition & Food Research, 60(10): 2288-2296 (2016)
・Oligonol, a lychee fruit-derived low-molecular form of polyphenol mixture, suppresses inflammatory cytokine production from human monocytes
Naeun Lee, Insoo Kang (Yale University School of Medicine, USA), et al.
Human Immunology, 77(6): 512-525 (2016)
・Low-molecular-weight polyphenols protect kidney damage through suppressing NF-κB and modulating mitochondrial biogenesis in diabetic db/db mice
Hung-Wen Liu, Chu-Chun Weia, Sue-Joan Chang (National Cheng Kung University, Taiwan)
Food & Function, 7(4): 1941-1949 (2016)
・Oligonol promotes anti-aging pathways via modulation of SIRT1-AMPK-Autophagy Pathway
Takako Yokozawa (Toyama University, Japan), Ok Sarah Shin (Korea University, Korea), et al.
Nutrition Research and Practice, 10(1): 3-10 (2016)
・Oligonol Ameliorates CCl4-Induced Liver Injury in Rats via the NK-Kappa B and MAPK Signaling Pathways
Takako Yokozawa (Toyama University, Japan), Ok Sarah Shin (Korea University, Korea), et al.
Oxidative Medicine and Cellular Longevity, Article ID 3935841 (2016)
・Inhibitory evaluation of oligonol on α-glucosidase, protein tyrosine phosphatase 1B, cholinesterase, and β-secretase 1 related to diabetes and Alzheimer’s disease
Takako Yokozawa (Toyama University, Japan), Hyun Ah Jung (Chonbuk National University, Korea), et al.
Archives of Pharmacal Research, 39(3), 409-420 (2016)
・Inhibitory effects of several saturated fatty acids and their related fatty alcohols on the growth of Candida albicans
Kazumi Hayama, Shigeru Abe (Teikyo University Institute of Medical Mycology, Japan), et al.
Drug Discoveries & Therapeutics, 9(6): 386-390 (2015)
・Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model
Jae-Yeo Park, Hyangkyu Lee (Yonsei University College of Nursing, Korea), et al.
BMC Complementary and Alternative Medicine, 15: 185 (2015)
・Oligonol suppresses lipid accumulation and improves insulin resistance in a palmitate-induced in HepG2 hepatocytes as a cellular steatosis model
Jae-Yeo Park, Hyangkyu Lee (Yonsei University College of Nursing, Korea), et al.
BMC Complementary and Alternative Medicine, 15: 185 (2015)
・Therapeutic Effects of Oligonol, Acupuncture, and Quantum Light Therapy in Chronic Nonbacterial Prostatitis
Hakan Akdere, Fatma Nesrin Turan (Trakya University, Turkey), et al.
Evidence-Based Complementary and Alternative Medicine, doi: org/10.1155/2015/687196 (2015)
・Protective role of oligonol from oxidative stress-induced inflammation in C6 glial cell
Jae Hyun Ahn, Eun Ju Cho (Pusan National University, Korea), et al.
Nutrition Research and Practice, 9(2): 123-128 (2015)
・Analgesic Effects of Oligonol, Acupuncture and Quantum Light Therapy on Chronic Nonbacterial Prostatitis
Hakan Akdere (Trakya University, Turkey), Mehmet Burgazli (Wuppertal Research and Medical center, Germany)et al.
Iranian Red Crescent Medical Journal, 17(4): e26006 (2015)
・Oligonol, a low-molecular-weight polyphenol derived from lychee fruit, attenuates gluco-lipotoxicity mediated renal disorder in type 2 diabetic db/db mice
Chan Hum Park, Takako Yokozawa (University of Toyama, Japan), et al.
Drug Discoveries & Therapeutics, 9(1): 13-22 (2015)
・Oligonol Supplementation Modulates Plasma Volume and Osmolality and Sweating After Heat Load in Humans.
Jeong Beom Lee (Soonchunhyang University, Korea), et al.
Journal of Medicinal Food, 18(5): 578-583 (2015)
・Oligonol improves memory and cognition under an amyloid β25-35-induced Alzheimer’s mouse model
Takako Yokozawa (University of Toyama, Japan), et al.
Nutrition Research, 34: 595-603 (2014)
・Anti-ice nucleating activity of polyphenol compounds against silver iodide
Seizo Fujikawa (Hokkaido University) et al.
Cryobiology, 69: 223-228 (2014)
・Beneficial effect of Oligonol supplementation on sweating response under heat stress in humans
Jeong Beom Lee, Young Oh Shin (Soonchunhyang University, Korea)
Food & Function, 5(10): 2516-2520 (2014)
・Inhibition of Adipogenesis by Oligonol through Akt-mTOR Inhibition in 3T3-L1 Adipocytes
Jae-Yeo Park, Hyangkyu Lee (Yonsei University College of Nursing, Korea), et al.
Evidence-Based Complementary and Alternative Medicine, doi: 10.1155/2014/895272 (2014)
・Effect of Lychee Fruit Extract (Oligonol) on Peripheral Circulation, a Pilot Study
Kentaro Kitadate, Kohei Homma (Amino Up Chemical Co., Ltd., Japan), et al.
Natural Medicine Journal, 6(7) (2014)
・Oligonol Supplementation Affects Leukocyte and Immune Cell Counts after Heat Loading in Humans
Jeong Beom Lee, Young Oh Shin (Soonchunhyang University, Korea)
Nutrients, 6(6), 2466-2477 (2014)
・Oligonol, a Low-Molecular-Weight Polyphenol Derived from Lychee Fruit, Attenuates Diabetes-Induced Renal Damage through the Advanced Glycation End Product-Related Pathway in db/db Mice
Chan Hum Park, Takako Yokozawa (Daegu Haany University, Korea), et al.
The Journal of Nutrition, 144(8): 1150-1157 (2014)
・Suppression of N-Methyl-N-Nitrosourea-Induced Retinal Damage in Mice by Oligonol, an Oligomerized Polyphenol Formulation
Jun Kisugi, Satoru Yui (Teikyo University) et al.
Advances in Biological Chemistry, 4, 138-147 (2014)
・The Anti-inflammatory Effects of Flavanol-rich Lychee Fruit Extract in Rat Hepatocytes
Tadayoshi Okumura (Kansai Medical University), Mikio Nishizawa (Ritsumeikan University) et al.
PLOS ONE, 9(4), e93818 (2014)
・Thirteen-week oral dose toxicity study of Oligonol containing oligomerized polyphenols extracted from lychee and green tea
Ashley Roberts (Intertek Cantox, Canada), Takahiro Maeda (Amino Up Chemical Co., Ltd., Japan), et al.
Regulatory Toxicology and Pharmacology, 68: 140-146 (2014)
・Evaluation of antiviral activity of Oligonol, an extract of Litchi chinensis, against betanodavirus
Toru Ichinose, Nobuyuki Kobayashi (Nagasaki University, Japan), et al.
Drug Discoveries & Therapeutics, 7(6): 254-260 (2013)
・Oligonol Inhibits Dextran Sulfate Sodium-Induced Colitis and Colonic Adenoma Formation in Mice
Hye-Won Yum, Young-Joon Surh (Seoul National University, Korea), et al.
Antioxidants & Redox Signaling, 19(2): 102-114 (2013)
・Oligomerized lychee fruit-derived polyphenol attenuates cognitive impairment in senescence-accelerated mice and endoplasmic reticulum stress in neuronal cells
Hideki Ohno, Tatsuya Sakurai (Kyorin University) et al.
British Journal of Nutrition, 28: 1-10 (2013)
・Analysis of supercooling activity of tannin-related polyphenols
Seizo Fujikawa (Hokkaido University) et al.
Cryobiology, 67: 40-49 (2013)
・Review: Evidence-based Clinical Research of Anti-obesity Supplements in Japan
Asuka Yasueda, Toshinori Ito, Kazuhiko Maeda (Osaka University Graduate School of Medicine, Japan)
Immunology, Endocrine & Metabolic Agents in Medicinal Chemistry, 13(3):185-195 (2013)
・Oligonol Supplementation Attenuates Body Temperature and the Circulating Levels of Prostaglandin E2 and Cyclooxygenase-2 After Heat Stress in Humans
Jeong-Beom Lee, Hun-Mo Yang (Soonchunhyang University, Korea), et al.
Journal of Medical Food, 16(4): 318-323 (2013)
・The Effect of Oligonol Intake on Leukocytes, Serum HSP70, and Body Temperature after heat stress
Young Oh ShinJeong, Beom Lee (Soonchunhyang University, Korea)
Journal of the Korean Society of Living Environmental System, 19(1), 137-145 (2012)
・Safety of oligonol, a highly bioavailable lychee-derived polyphenolic antioxidant, on liver, kidney and heart function in rats
Mahesh Thirunavukkarasu (University of Connecticut Health Center, USA), Manashi Bagchi (NutriToday LLC, USA), et al.
Toxicology Mechanisms and Methods, 22(7): 555-559 (2012)
・Oligonol-induced Degradation of Perilipin 1 is Regulated through Lysosomal Degradation Machinery
Junetsu Ogasawara, Hideki Ohno (Kyorin University) et al.
Natural Product Communications, 7(9): 1193-1196 (2012)
・Oligomerized lychee fruit extract (OLFE) and a mixture of vitamin C and vitamin E for endurance capacity in a double blind randomized controlled trial
Seung Wan Kang, Sang Chul Lee, et al. (Seoul National University Hospital, Korea)
Journal of Clinical Biochemistry and Nutrition, 50(2): 106-113 (2012)
・Effect of Oligonol Intake on Cortisol and Cytokines, and Body Temperature after Leg Immersion into Hot Water
Young-Oh Shin, Jeong-Beom Lee, et al. (College of Medicine, Soonchunhyang University, Korea)
Food Science Biotechnology, 20(3): 659-663 (2011)
・Treatment with Oligonol, a low-molecular Polyphenol derived from lychee fruit, attenuates diabetes-induced hepatic damage through regulation of oxidative stress and lipid metabolism
Jeong Sook, Chan Hum Park, Takako Yokozawa (University of Toyama)
British Journal of Nutrition, 106: 1013-1022 (2011)
・Antioxidant Therapy as a Potential Approach to Severe Influenza-Associated Complications
Noboru Uchide, Hiroo Toyoda (Tokyo University of Pharmacy and Life Sciences, Japan)
Molecules, 16: 2032-2052 (2011)
・Effects of Oligonol(R), an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid
Yuji Moriwaki (Hyogo College of Medicine) et al.
Journal of Functional Foods, 3, 13-16 (2011)
・Supplementation with a Flavanol-rich Lychee Fruit Extract Influences the Inflammatory Status of Young Athletes
Mikio Nishizawa, Tadao Isaka (Ritsumeikan University) et al.
Phytotherapy Research, 25(10): 1486-1493 (2011)
・Comparison of the Effect of Oligonol, A New Lychee Fruit-derived Low Molecular Form of Polyphenol, and Epigallocatechin-3-gallate on Lipolysis in Rat Primary Adipocytes
Junetsu Ogasawara, Hideki Ohno (Kyorin University) et al.
Phytotherapy Research, 25(3): 467-471 (2010)
・Oligonol, an oligomerized lychee fruit-derived polyphenol, activates the Ras/ Raf-1/ MEK1/2 cascade independent of the IL-6 signaling pathway in rat primary adipocytes
Junetsu Ogasawara, Hideki Ohno (Kyorin University) et al.
Biochemical and Biophysical Research Communications, 402, 554-559 (2010)
・The effect of Oligonol intake on cortisol and related cytokines in healthy young men
Jeong-Beom Lee, Hun-Mo Yanga, et al.(Soonchunhyang University, Korea)
Nutrition Research and Practice, 4(3): 203-207 (2010)
・Hypolipidaemic and antioxidative effects of oligonol, a low-molecular-weight polyphenol derived from lychee fruit, on renal damage in type 2 diabetic mice
Takako Yokozawa (University of Toyama) et al.
British Journal of Nutrition, 104(8): 1120-1128 (2010)
・Oligonol a low molecular weight polyphenol of lychee fruit extract inhibits proliferation of influenza virus by blocking reactive oxygen species-dependent ERK phosphorylation
Mehran Haidari, et al.(The University of Texas Health Science Center at Houston, USA)
Phytomedicine, 17(13): 1047-1056 (2010)
・Bioactivity of a flavanol-rich lychee fruit extract in adipocytes and its effects on oxidant defense and indices of metabolic syndrome in animal models
Carl L. Keen, Robert M. Hackman, et al. (University of California, Davis, USA)
Phytotherapy Research 24(8): 1223-1228 (2010)
・Beneficial effect of the oligomerized polyphenol oligonol on high glucose-induced changes in eNOS phosphorylation and dephosphorylation in endothelial cells
Hiroki Yokoo, Yuichi Hattori, et al. (University of Toyama)
British Journal of Pharmacology, 159: 928-938 (2010)
・Oligomerized grape seed polyphenols attenuate inflammatory changes due to antioxidative properties in coculture of adipocytes and macrophages
Hideki Ohno, Tatsuya Sakurai (Kyorin University) et al.
Journal of Nuritional Biochemistry, 21: 47-54 (2010)
・Amelioration of abdominal obesity by low-molecular-weight polyphenol (Oligonol) from lychee
Jun Nishihira, Maremi Sato-Ueshima, et al. (Hokkaido Information University, Japan)
Journal of Functional Foods, 1(4): 341-348 (2009)
・Oligonol, a new lychee fruit-derived low-molecular form of polyphenol, enhances lipolysis in primary rat adipocytes through activation of the ERK1/2 pathway
Junetsu Ogasawara, Hideki Ohno (Kyorin University) et al.

Phytotherapy Research, 23: 1626-1633 (2009)
・Inhibition of Lung Metastasis in Mice by Oligonol
Sung-Jae Lee, Hyung-In Moon, et al. (Wonkwang University, Korea)
Phytotherapy Research, 23: 1043-1046 (2009)
・Preventive Effects of Oligomerized Polyphenol on Estradiol-Induced Prostatitis in Rats
Dong Suk Kim, Sung Joon Hong, et al. (Yonsei University College of Medicine, Seoul, Korea)
Yonsei Medical Journal, 50(3): 391-398 (2009)
・Oligonol, a lychee fruit-derived low molecular weight polyphenol formulation, inhibits UVB-induced cyclooxygenase-2 expression, and induces NAD(P)H:quinone oxidoreductase-1 expression in hairless mouse skin
Joydeb Kumar Kundu, Young-Joon Surh, et al. (Seoul National University, Korea)
Journal of Functional Foods, 1(1): 98-108 (2009)
・Inhibitory effects of oligonol on phorbol ester-induced tumor promotion and COX-2 expression in mouse skin: NF-κB and C/EBP as potential targets
Joydeb Kumar Kundu, Young-Joon Surh, et al. (Seoul National University, Korea)
Cancer Letters, 273: 86-97 (2008)
・The Function of the Next Generation of Polyphrnol “Oligonol”
Takehito Miura, Kentaro Kitadate (Amino Up Chemical Co., Ltd.)
Japanese Society for Complementary and Alternative Medicine Journal 5(3): 163-171 (2008)
・Acute, subchronic and genotoxicity studies conducted with Oligonol, an oligomerized polyphenol formulated from lychee and green tea extracts
Bernadene A. Magnuson, Ashley Roberts (Cantox Health Sciences International, Canada), et al.
Food and Chemical Toxicology, 46(12): 3553-3562 (2008)
・The Supplementation of Oligonol, the New Lychee Fruit-derived Polyphenol Converting into a Low-molecular Form, Has a Positive Effect on Fatigue during Regular Track-and-field Training in Young Athletes
Hideki Ohno, Tatsuya Sakurai (Kyorin University) et al.
Advances in Exercise and Sports Physiology, 13(4): 93-99 (2008)
・Anti oxidative effects of a new lychee fruitderived polyphenol mixture, Oligonol, converted into a low-molecular form in adipocytes
Tatsuya Sakurai, Hideki Ohno (Kyorin University) et al.
Bioscience, Biotechnology, and Biochemistry, 72(2): 463-476 (2008)
・Oligonol Inhibits UVB-induced COX-2 Expression in HR-1 Hairless Mouse Skin―AP-1 and C/EBP as Potential Upstream Targets
Joydeb Kumar Kundu, Young-Joon Surh, et al. (National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul National University, Korea)
Photochemistry and Photobiology, 84: 399-406 (2008)
・Flavanols: digestion, absorption and bioactivity
Robert M. Hackman, Carl L. Keen, et al. (University of California, Davis, USA)
Phytochemistry Reviews, 7: 195-208 (2008)
・Platelet Reactivity in Male Smokers Following the Acute Consumption of a Flavanol-Rich Grapeseed Extract
Carl L. Keen, Robert M. Hackman, et al. (University of California, Davis, USA)
Jounal of Medicinal Food, 10(4): 725-730 (2007)
・Modulation of infection-induced inflammation and locomotive deficit and longevity in senescence-accelerated mice-prone (SAMP8) model by the oligomerized polyphenol Oligonol
Koji Tomobe(Amino Up Chemical Co., Ltd.), Okeizie I. Aruoma(Touro College of Pharmacy, USA), et al.
Biomedicine & Pharmacotherapy, 61: 427-434 (2007)
・Preparation, Characterization, and Antioxidative Effects of Oligomeric Proanthocyanidin-L-Cysteine Complexes
Hajime Fujii (Amino Up Chemical Co., Ltd.), Gen-ichiro Nonaka (Usaien Pharmaceutical Co., Ltd.), et al.
Journal of Agricultural and Food Chemistry, 55(4): 1525-1531 (2007)
・Induction of apoptosis in MCF-7 and MDA-MB-231 breast cancer cells by Oligonol is mediated by Bcl-2 family regulation and MEK/ERK signaling
Jo, Eun-Hye, Kyung-Sun, et al. (Seoul National University, Korea)
European Journal of Cancer Prevention, 16(4): 342-347 (2007)
・Evaluation of the safety and toxicity of the oligomerized polyphenol Oligonol
Hajime Fujii, Buxiang Sun (Amino Up Chemical Co., Ltd.), Okezie I. Aruoma (London South bank University, UK), et al.
Food and Chemical Toxicology, 45: 378-387 (2007)
・Protective effect of grape seed polyphenols against high glucose-induced oxidative stress
Hajime Fujii (Amino Up Chemical Co., Ltd.), Gen-ichiro Nonaka (Usaien Pharmaceutical Co., Ltd.), et al.
Bioscience, Biotechnology, and Biochemistry, 70(9): 2104-2111 (2006)
・Low molecular proanthocyanidin dietary biofactor Oligonol: Its modulation of oxidative stress, bioefficacy, neuroprotection, food application and chemoprevention potentials
Okezie I. Aruoma (London South bank University, UK), Vidushi S. Neergheen, Theeshan Bahorun (University of Mauritius, Republic of Mauritius), et al.
Bio Factors, 27(1-4): 245-265 (2006)
・Comparative efficacy of Oligonol, catechin and (-)-epigallocatechin 3-O-gallate in modulating the potassium bromate-induced renal toxicity in rats
Hiroshi Nishioka, Hajime Fujii, Buxiang Sun (Amino Up Chemical Co., Ltd.), Okezie I. Aruoma (London South bank University, UK)
Toxicology, 226: 181-187 (2006)
・Protective Effects of Oligonomers og Grape Seed Polyphenols Against b-Anyloid-Induced Oxidative Cell Death
Mei-Hua Li, Young-Joon Surh (Seoul National University, Korea)
Annals of the New York Academy of Sciences, 1030: 317-329 (2004)