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AHCC® Research Presentations

AHCC®の学会発表

AHCC® Conference Presentation List

2016
Dec.APNNO (Asia-Pacific Nutrigenomics & Nutrigenetics Organization)
「Beneficial effects of Active Hexose Correlated Compound (AHCC) again cancer」
Kenji Sato, Faculty/ Graduate School of Agriculture, Kyoto University
Sep.38th ESPEN Congress
「Alleviating Effect of Active Hexose Correlated Compound Prevents Endotoxin-Induced Liver Injury after Partial Hepatectomy in Rats」
Richi Nakatake, Tadayoshi Okumura et al. (Kansai Medical University)
Feb.25th Conference of the Asian Pacific Association for the Study of the Liver (APASL 2016)
「The Effect of Addition AHCC on HBsAg Level in Patients with CHBeAg negative on Long Term Nucleos(t)ide analogues (NUCs) Treatment」
Anuchit Chutaputti (Phramongkutklao Hospital, Thailand), et al.
2015
Nov.ICoFF 2015
「Identification of anti-inflammatory compounds in extract of cultured edible mushroom」
Maki Kashimoto, Kenji sato(Kyoto University) et al.
Nov.SIO 2015 (12th International Conference of the Society for Integrative Oncology)
「MicroRNA Signature in the Chemoprevention of Breast Cancer by Active Hexose Correlated Compound (AHCC): the Involvement of Tumor Suppressor MIR-335」
Emilie Graham, Chantal Matar (University of Ottawa, Canada), et al.
「Integrated Treatment in Metastatic Pancreatic Cancer: Complete Remission in Two Cases」
Massimo Bonucci (Feliciano Hospital, Italy), et al.
Nov.9th International HHV-6 & 7 Conference
「Active Hexose Correlated Compound (AHCC) inhibited reactivation of HHV-6 in the advanced cancer patients receiving chemotherapy.」
Hajime Fujii (Amino Up Chemical Co., Ltd.) Toshinori Ito (Osaka University) et al.
Oct.International neurology conference Pacific Neuro School
「What is “functional food”? Evaluation of ETAS and AHCC efficacy」
Jun Takanari (Amino Up Chemical Co., Ltd.)
Jul.ICMI 2015 (International Congress of Mucosal Immunology)
「The intestinal epithelial cells and toll-like receptors TLR-2 and TLR-4 involvement in immune modulatory effect of AHCC」
Yosuke Hirayama, Hajime Fujii (Amino Up Chemical, Japan), Chantal Matar (University of Ottawa, Canada), et al.
Jan.HRP IWS 2015 (NASA)
「AHCC activates human lymphocytes via phenotypic , genotypic and differentiation changes to an adherent cell type. A possible novel mechanism of activation.」
Loretta Olamigoke, Alamelu Sundaresan (Texas Southern University, USA), et al.
2014
Oct.SIO 2014
「Evaluation of active hexose correlated compound (AHCC) for the Eradication of HPV Infections in Women with HPV positive Pap Smears」
Judith A. Smith, Teresa T Byrd (The University of Texas Health Science Center, USA), et al.
Sep.3rd International Conference and Exhibition on Clinical & Cellular Immunology
「AHCC use and one daring hypothesis」
Francisco Karkow (The Nutrition and Metabolic Department of the Fatima Faculty, Brazil), Anil D. Kulkarni (University of Texas Health Science center and Medical School, USA), et al.
Sep.ESPEN 2014
「Effects of AHCC on autonomic nervous function」
Takehito Miura (Amino Up Chemical Co., Ltd.) Tatsuya Hisajima (Heisei Teikyo University)et al.
Jun.FASEB 2nd International Conference on Retinoids
「AHCC Modulates Hypertension Via the Nitric Oxide Signaling Pathway in Rats.」
Marie Francoise Doursout, Anil Kulkarni (University of Texas Medical School at Houston, USA), et al.
Apr.Experimental Biology 2014
「Role of Intestinal epithelial cells and involvement of TLRs in immune effects of AHCC」
Jean-Francois Mallet, Chantal Matar (University of Ottawa, Canada), et al.

「Inhibitory Effect of AHCC and GCP on Tumorigenesis of C6 Glioma Cells in Culture Medium and in Rats Mediated by Downregulating CD133 and Nestin Expressions」
Xiao-Hong Zhang, Hiroshi Nishioka, Hajime Fujii (Amino Up Chemical Co., Ltd.)
Mar.SGO 45th Annual meeting on Women’s Cancer
「In vitro and in vivo evaluation of Active Hexose Correlated Compound (AHCC) for the Eradication of HPV」
Judith Smith (MD Anderson Cancer Center, USA), et al.
Feb.The 9th Annual Meeting of Thai Association for the Study of the Liver
「Role of AHCC in Liver disease」
Jun Nishihira (Hokkaido Information University)
Feb.ASPEN Clinical Nutrition Week 2014
「Effects of active hexose correlated compound (AHCC) on survival in a murine peritonitis model and on macrophage function」
Motonari Ri, Yasuyuki Seto (The University of Tokyo, Japan), et al.
2013
Oct.(First ISS-ARTOI Conference on Integrative Oncology Fifth ARTOI International Congress)
「AHCC: Impact on the Immunological System of Patients with Disseminated Neuroendocrine Tumors After Treatment with the Radioisotope preparation (90Y-DOTA-TATE) – An Initial Report」
Norbert Szalus (Radionuclide Therapy and Nuclear Medicine, Central Clinical Hospital of Ministry of Interior, Warsaw, Poland), et al.
Aug.ESPEN 2013
“Effect of Bifidus BB536 and Active Hexose Correlated Compound on Immune Function in Healthy Individuals”
Abeed H. Chowdhury, Dileep N. Lobo (University of Nottingham, UK), et al.

“Alleviating Effect of AHCC for Chemotherapy-related Side Effects in Unresectable Pancreas Cancer Patients”
H. Yanagimoto et al. (Kansai Medical University)
May.14th Clinical Applications for Age Management Medicine
“Nutritional Management of Diseases of Overt Inflammation: Impact on Cancer and Diabetes”
Okezie I. Aruoma (American University of Health Sciences, USA)
Feb.ASPEN Clinical Nutrition Week 2013
“Effect of Active Hexose-Correlated Compound in Woman Receiving Adjuvant Chemotherapy for Breast Cancer: A Retrospective Study”
Tempei Miyaji (Tokyo University) et al.

“The influence of active hexose correlated compound (AHCC) supplementation on 5-fluorouracil (5-FU)-induced impairment of gut immunity”
Shunsuke Amenomori, Kazuhiko Fukatsu (Tokyo University Hospital Surgical Center) et al.

“Effects of Active Hexose Correlated Compound on Lifespan and Stress Resistance of C. elegans”
Tetsuya Okuyama, Mikio Nishizawa (Ritsumeikan University) et al.
2012
Oct.SIO 2012
“Evaluation Of Active Hexose Correlated Compound (AHCC) In Combination With Cisplatin For Prevention Or Delay Of Tumor Growth In Human Cervical Cancer Xenograft Model”
Judith Smith (MD Anderson Cancer Center), et al.
Sep.34th ESPEN Congress
“Adenosine, a hepato-protective compound in AHCC”
Hirokazu Miki, Yoshito Tanaka (Kansai Medical University) et al.
Jun.EAWM 2012
“The effect of the functional food active hexose correlated compound on lifespan and stress resistance of C. elegans”
Tetsuya Okuyama, Mikio Nishizawa (Ritsumeikan University) et al.
May.International Meeting of EARA
“AHCC – experience in the support treatment of cancer and chronic diseases.”
Norbert Szalus (Military Institute of Medicine, Poland)

“Observational Study with AHCC on Cancer Patients”
Massimo Bonucci (ARTOI, Italy)

“AHCC as prebiotic and synergic effect with probiotics”
Mercedes Ortega Gonzalez (Universidad de Granada, Spain)
2011
Nov.2011 ISNFF Conference and
Exhibition
“Mushroom nutraceuticals for chronic inflammation and intestinal health”
Robert M. Hackman (University of California, USA)

“AHCC supplementation as a potential countermeasure for space environmental effects on immune system and implications in aging and as functional food.”
Anil D. Kulkarni (The University of Texas, USA)

“Combinational effects of AHCC and lactobacillus in immunecompromised or anticancer drug-treated mice”
Takahiro Maeda (Amino Up Chemical, Co., Led., Japan)

“Renaissance of cultural and ethnic nutrition in Global Health Era: Role of Immunonutrients”
Anil D. Kulkarni (The University of Texas, USA)
Nov.SIO 2011 (8th Annual International Conference of the Society for Integrative Oncology)
“Exploratory Clinical Research on Active Hexose-Correlated Compound: Effect of Active Hexose-Correlated Compound on Patients with Breast Cancer Treated with Adjuvant Chemotherapy”
Sho Hangai (Tokyo University)

“The Basidiomycota Mushroom, Lentinula edodes: Mechanisms, Perspectives and Applications”
Jillian Capodice, et al. (Columbia University, USA)
Jun.ICMI 2011 (15th International Congress of Mucosal Immunology)
“Immunomax /Active Hexose Correlated Compound induces in vitro production of interleukin -12 and interferon -α & γ by PBMC-derived mononuclear cells from subjects with recurring Herpes simplex type 1 and 2 infections.”
George Drannik, et al. (National Medical University, Ukraine)
Apr.2nd Congresso Internazionale di Medicina Biointegrata
“AHCC Use in Integrative Medicine”
Kohei Homma(Amino Up Chemical Co., Ltd.)
Apr.Experimental Biology meeting
“AHCC Increases the Percent of Natural Killer Cells Post Influenza Vaccination”
Elizabeth M. Gardner, et al. (Michigan State University, USA)
2010
Nov.SIO 2010 (7th Annual International Conference of the Society for Integrative Oncology)
“Active Hexose Correlated Compound (AHCC) Reduces a Variety of Anticancer Drug-Induced Side Effects in Mice”
Koji Wakame (Amino Up Chemical Co., Ltd.) et al.
Oct.2010 ISNFF Conference and Exhibition
“Enhancing Mushroom Power ― The AHCC Story”
Robert M. Hackman (University of California, Davis, USA)

“Suppression of NO and iNOS Production in Primary Cultured Hepatocytes by Mono-Saccharide Fraction of AHCC”
Kenji Sato (Kyoto University)
Sep.32nd ESPEN (European Society for Clinical Nutrition and Metabolism)
“Active Hexose Correlated Compound (AHCC) supplementation changes cellular responses of healthy subjects”
Elizabeth Gardner, et al. (Michigan State University)

“Effect of AHCC on the mucosal immune system of the mice with intestinal candidiasis”
Tetsuya Hisajima (Teikyo Heisei University)
Apr.Experimental Biology meeting
“Active Hexose Correlated Compound (AHCC) improves immune cell populations after influenza vaccination of healthy subjects.”
Elizabeth Gardner(Michigan State University)
Mar.Conference on Nutrition and Cancer-2010
“Functional Foods in Cancer Therapy”
Anil D. Kulkarni(The University of Texas, USA)
2009
Nov.SIO 2009 (8th Annual Society for Integrative Oncology Conference)
“Evaluation of safety and efficacy of active hexose correlated compound (AHCC) in combination with liposomal doxorubicin”
Judith A. Smith(The University of Texas MD Anderson Cancer Center, USA)

“Integrated lifestyle intervention on metabolic parameters for the prostate cancer patient receiving androgen deprivation therapy”
Kazuhisa Maeda (Osaka University) et al.
Nov.40th APA (American Pancreatic Association)
“The beneficial effect of active hexose correlated compound (AHCC), a health food component, in patients with pancreatic or biliary tract cancer who underwent chemotherapy”
Hiroaki Yanagimoto (Kansai Medical University) et al.
Oct.ICN 2009 (19th International Congress of Nutrition)
“Active Hexose Correlated Compound (AHCC) Reduces Anticancer Drug-Induced Side Effects in Mice”
Robert M. Hackman(University of California, Davis, USA)
Sep.31th ESPEN (European Society for Clinical Nutrition and Metabolism)
“The Beneficial Effect of Active Hexose Correlated Compound (AHCC), a Health Food Component, in Patients with Pancreatic or Biliary Tract Cancer who underwent Chemotherapy”
Hiroaki Yanagimoto (Kansai Medical University) et al.

“Active Hexose Correlated Compound Regulates Enterocyte Response and Differentiation”
Olga Martinez-Augustin (University of Granada) et al.
May.3rd Asian Pacific ISSX Meeting
「Chemicals and Biomodifiers to Prevent Cancer and Malformation」
Taisei Nomura (National Institute of Biomedical Innovation)
Feb.ASPEN (American Society of Parenteral and Enteral Nutrition)
「Dietary Nucleotides: Present Status and Future Directions」
Anil D. Kulkarni (University of Texas, Medical School, USA)

「Dietary Substrates: Fruit and Plant」
Toshinori Ito (Osaka University)

“Alleviating Function of Active Hexose Correlated Compound (AHCC), a health food component, for Side Effect in Chemotherapy Patients”
Hiroaki Yanagimoto (Kansai Medical University)
2008
Nov.4th International Niigata Symposium on Diet and Health
“Basic and clinical studies on anti-tumor effect and anti-oxidantive function of natural products
Masatoshi Yamasaki (Teikyo University)
Oct.67th Annual Meeting of the Japanese Cancer Association
Alleviating effect of AHCC for multiple anticancer drug-induced side effects
Hiroshi Nishioka, Koji Wakame (Amino Up Chemical Co., Ltd.)
Sep.30th ESPEN (European Society for Clinical Nutrition and Metabolism)
“Dietary Active Hexose Correlated Compound, A Polysaccharide Mushroom Extract, Decreases Ischemia/Reperfusion Injury”
Anil D. Kulkarni (The University of Texas Medical School and GSBS, Houston, USA)
Aug.5th International Conference of the Nitric Oxide Society
Active hexose-correlated compound (AHCC) inhibits the induction of iNOS gene expression in proinflammatory cytokine-stimulated hepatocytes
Mikio Nishizawa (Ritsumeikan University)

Insulin-like growth factor-I prevents liver injury through the inhibition of inflammatory cytokine and iNOS induction in a rat model of acute liver failure
Tadayoshi Okumura (Ritsumeikan University)
Apr.Experimental Biology 2008
“Effects of Active Hexose Correlated Compound on humoral immunity in food-deprived mice immunized with ovalbumin”
H.O. Aviles, P. O’Donnell, J. Orshal, D. Sen, H. Fujii and G. Sonnefeld (Binghamton Univ. and Amino Up Chemical Co. Ltd., Sapporo)
Feb.Aspen
“Nutritional intervention: Active hexose correlated compound enhances immune function in animal analog of aging and microgravity effects.”
Mari Kogiso, Anil D. Kulkarni, et al. (The University of Texas Medical School and GSBS, Houston, USA)
2007
Dec.ICMAA-2007
“Enhancing Mushroom Power: The AHCC Story”
Rovert M. Hackman(Department of Nutriton, University of California Davis, CA, USA)

“Prevention of Cancer and Malformation by Bioactive Substances in Mice” Taisei Nomura(Graduate School of Medicine, Osaka University and National Institute of Viomedical Innovation, Osaka, Japan
Sep.29th ESPEN (European Society for Clinical Nutrition and Metabolism)
“Involvement of AHCC in expression of inducible nitric oxide synthase gene and relating genes”
M. Nishizawa(Department of Bioscience and Biotechnology, Faculty of Science and Engineering, Ritsumeikan University), T. Okumura(Department of Medical Chemistry, Kansai Medical University)
Apr.AACR Annual Meeting (Los Angels, CA)
“Active Hexose Correlated Compound enhances chemotherapeutic effect of 5-FU”
Zhinan Yin (Yale Univ., *Amino Up Chemical Co., Ltd.)
Jan.Aspen Summit(Colorado)
“Effect of Active Hexose Correlated Compound on the Production of Nitric Oxide in Hepatocytes”
Kosuke Matsui, Tadayoshi Okumura (Kansai Medical University)

“Nutritional Effects of Active Hexose Correlated Compound: Immune Restoration in Stress Mouse Model”
Koji Wakamatsu, Anil D. Kulkarni (University of Texas)
2006
Nov.APOCP(Asian Pacific Organization for Cancer Research)(Chiang Mai,Thailand)
“Molecular and Clinical Outcomes of GCP in Prostate and Lymphoid Cancers”
Robert M. Hackman(UC Davis)

“GCP for Primary and Secondary Prevention of Prostate and Lymphoma Cancers”
Robert M. Hackman(UC Davis)
May.American Association of Immunologists Annual Meeting in Boston (Boston, USA)
“AHCC enhances resistance to infection in a surgical wound infection model”
P. O’Donnell, H. Aviles, J. Orshal, B. Sun* and G. Sonnenfeld (Binghamton Univ., * Amino Up Chemical Co., Ltd.)
Apr.97th American Association for Cancer Research Annual Meeting (Washington, DC, USA)
“Active Hexose Correlated Compound (AHCC) enhances tumor surveillance through regulating both innate and adaptive immune responses”
Y. Gao, B. Sun*, H. Fujii*, K. Kosuna* and Z. Yin (Yale Univ., *Amino Up Chemical Co., Ltd.)
2005
Nov.Food and Chemical Toxicology
“Safety of AHCC in Healthy Volunteers”
Dr.Walshe
Sep.3rd meeting of the Korean Society of Complementary & Alternative Medicine
“The Application of CAM in the Patients with Digestive Disease”
Toshinori Ito (Osaka University)
2004
Mar.95th Annual Meeting of American Association for Cancer Research(AACR)(Orlando,Florida)
“Effects and mechanisms of AHCC and GCP in tumors”
Buxiang Sun (Amino Up Chemical Co., Ltd.)
Jan.6th Joint Conference of the AACR and JCA
“Effects and mechanisms of AHCC and GCP in tumors”
Buxiang Sun (Amino Up Chemical Co., Ltd.)

“AHCC Enhances Tumor Immunosurveillance by Up-regulating the Antigen-specific CD8+ IFN-γ Production”
Zhinan Yin, et al. (Yale School of Medicine, USA)
2002
Apr.93rd Annual Meeting of American Association for Cancer Research (AACR)
“Antitumor effects of AHCC and GCP in hepatocarcinogenetic mice”
Buxiang Sun (Amino Up Chemical Co., Ltd.)
2001
Dec.4th meeting of the Japan Society for Biological Therapy
“Anti-tumor effect of AHCC and GCP in hepatocarcinogenic mice”
Tomomi Mukaida (Amino Up Chemical Co., Ltd) et al.
Mar.92nd Annual Meeting of American Association for Cancer Rsearch (AACR)
“Synergistic anti-tumor effects of mushroom polysaccharides (AHCC) and aglycone isoflavones(GCP) on prostate and other cancers”
B. Sun et al. (Amino Up Chemical Co., Ltd.)
2000
Jun.35th Congress of the Europian Society for Surgical Research
“Hepatobiliary and Pancreatic Surgery”
Y. Kamiyama (Kansai Medical University) et al.
1999
Apr.34th Congress of the European Society for Surgical Research
“Improving effect of AHCC on the prognosis of postoperative hepatocellular carcinoma patients”
Y.Kamiyama (Kansai Medical University) et al.
Apr.90th American Association for Cancer Research (Philadelphia, USA)
“Reduction of side effects of anticancer drugs by active hexose correlated compound”
B.Sun (Amino Up Chemical Co., Ltd.) et al.
1998
Oct.4th International Symposium on Predictive Oncology and Therapy (Nice, France)
“Reduction of side effects of anti-cancer drugs by AHCC, mycelian extracts of cultured basidiomycetes”
B. Sun (Amino Up Chemical Co., Ltd) et al.
Apr.33rd Congress of the European Society for Surgical Research
“Preventive effect of AHCC on the recurrence of postoperative hepatocellular carcinoma patients”
H.Kitade (Kansai Medical University) et al.
1997
May.32nd Congress of the European Society for Surgical Research
Immunotherapy with AHCC in hepatocellular carcinoma patients
S.Tasaki (Kansai Medical University) et al.