Amino Up Chemical 株式会社アミノアップ化学

PMP

PMP (Polyphenolic Mixture of Plant: Phenolic compound derived from plants) is a new natural antioxidation agent made by independent refining of active constituents such as "polyphenol" etc. that are contained in the "Fruit of Soba" which is originated in Hokkaido.

論文・学会発表一覧

What is PMP

PMP (Polyphenolic Mixture of Plant) is a product that is obtained by independent refining of active constituents such as "polyphenols" etc, contained in the "'buckwheat " which is originated in Hokkaido.

Constituents

Buckwheat is used as the raw material of PMP. After harvesting, the buckwheat is washed, dried and crushed in strict hygienic and environmental control and polyphenol is extracted by independent method. Thereafter, the impurities are removed and the polyphenol is refined. Polyphenol contains a lot of oligomers of catechin and epicatechin.

Around 80 percent of the PMP polyphenol is constituted by oligomers of catechin and epicatechin. (A patent application has been filed for this new product). Rutin and quercetin are also present in small amounts.

Safety

PMP can be classified as general food stuff, and till now there have been no reports of adverse effects of buckwheat (Knotweed, Fagopyrum esculentum Moench) or its contitutents in the human body.

No adverse effects were seen in the tests conducted and monitored in healthy volunteers for a period of 1 month.
Moreover, various safety tests were carried out and it was confirmed that PMP is a safe foodstuff.

※However, those who are allergic to Soba should be careful at the time of intake.

Efficiency

It is known that PMP protects the kidney and brain from the negative effects of active oxygen. With aging, the functional capacity of internal body organs decreases due to active oxygen etc., but PMP protects the organs.

PMP demonstrated anti-oxidative effects during tests. Its radical-scavenging ability is much stronger than the polyphenols contained in catechin, rutin, and quercetin of Soba and it is expected to have a protective effect against the lessening function of kidneys, diabetes and hyperlipemia.

After administering PMP, the before and after LPO (lipid peroxide) concentration and SOD (active oxygen excision enzyme) activity were compared. On an average the LPO concentration decreased by 19% while the SOD activity increased by 16%.

It was understood that PMP demonstrates an antioxidative effect in the human body when taken orally.

PMP demonstrates an antioxidative effect in brain also, thus preventing lessening of function caused due to the oxidation of brain cells.

Further, PMP shows a remarkable preventive effect against the β amyloid protein which causes the neurotoxic Alzheimer's disease.

PMP is also administered in patients suffering from hyperlipemia and arteriosclerosis. This antioxidative effect of PMP leads to improvement in hyperlipemia, prevention of arteriosclerosis, or decrease in serum cholesterol etc.

Although vascular dilatation technique with balloon is used for atherosclerosis, there is a possibility of restenosis with the passage of time after the technique. PMP administration has prevent restenosis by maintaining the open state of blood vessels.